Michael Sinterniklaas ... Leonardo (voice) Wayne Grayson ... Michelangelo (voice) Sam Riegel ... Donatello (voice) Frank Frankson ... Raphael (voice) (as Greg Abbey) Darren Dunstan ... Splinter (voice) Marc Thompson ... Casey Jones (voice) Veronica Taylor ... April O'Neil (voice) Scottie Ray ... The Shredder / Ch'rell (voice) Greg Carey ... Hun (voice) Karen Neil ... Karai (voice) Dan Green ... Leonardo 88' (voice) Johnny Castro ... Michelangelo 88' / Rocksteady (voice) Anthony Salerno ... Donatello 88' (voice) Sebastian Arcelus ... Raphael 88' (voice) David Wills ... Splinter 88' / Mirage Shredder (voice)
George Clooney ... Mr. Fox (voice) Meryl Streep ... Mrs. Fox (voice) Jason Schwartzman ... Ash (voice) Bill Murray ... Badger (voice) Wallace Wolodarsky ... Kylie (voice) (as Wally Wolodarsky) Eric Chase Anderson ... Kristofferson (voice) (as Eric Anderson) Michael Gambon ... Franklin Bean (voice) Willem Dafoe ... Rat (voice) Owen Wilson ... Coach Skip (voice) Jarvis Cocker ... Petey (voice) Wes Anderson ... Weasel (voice) Karen Duffy ... Linda Otter (voice) Robin Hurlstone ... Walter Boggis (voice) Hugo Guinness ... Nathan Bunce (voice) Helen McCrory ... Mrs. Bean (voice)
Cedric the Entertainer ... Maurice (voice) Andy Richter ... Mort (voice) Carl Reiner ... Santa (voice) Danny Jacobs ... King Julien Jada Pinkett Smith ... Gloria (voice) Chris Rock ... Marty (voice) David Schwimmer ... Melman (voice) Ben Stiller ... Alex (voice)
Jim Carrey ... Scrooge / Ghost of Christmas Past / Scrooge as a Young Boy / Scrooge as a Teenage Boy / Scrooge as a Young Man / Scrooge as a Middle-Aged Man / Ghost of Christmas Present / Ghost of Christmas Yet to Come (voice) Steve Valentine ... Funerary Undertaker / Topper (voice) Daryl Sabara ... Undertaker’s Apprentice / Tattered Caroler / Beggar Boy / Peter Cratchit / Well-Dressed Caroler (voice) Sage Ryan ... Tattered Caroler (voice) Ryan Ochoa ... Tattered Caroler / Beggar Boy / Young Cratchit Boy / Ignorance Boy / Young Boy with Sleigh / Tiny Tim (voice) Bobbi Page ... Tattered Caroler / Well-Dressed Caroler (voice) Ron Bottitta ... Tattered Caroler / Well-Dressed Caroler (voice) Sammi Hanratty ... Beggar Boy / Young Cratchit Girl / Want Girl (voice) Julian Holloway ... Fat Cook / Portly Gentleman #2 / Business Man #3 (voice) Gary Oldman ... Bob Cratchit / Marley / Tiny Tim (voice) Colin Firth ... Fred (voice) Cary Elwes ... Portly Gentleman #1 / Dick Wilkins / Mad Fiddler / Guest #2 / Business Man #1 (voice) Robin Wright Penn ... Fan / Belle (voice) Bob Hoskins ... Mr. Fezziwig / Old Joe (voice) Jacquie Barnbrook ... Mrs. Fezziwig / Fred’s Sister-in-Law / Well-Dressed Caroler (voice)
Kristen Bell ... Cora (voice) Nicolas Cage ... Dr. Tenma (voice) Samuel L. Jackson ... Zog (voice) Charlize Theron ... 'Our Friends' Narrator (voice) Bill Nighy ... Dr. Elefun (voice) Freddie Highmore ... Astro Boy (voice) Donald Sutherland ... General Stone (voice) Eugene Levy ... Orrin (voice) Nathan Lane ... Ham Egg (voice) Moises Arias ... Zane (voice) Sterling Beaumon ... Sludge (voice) Matt Lucas ... Sparx (voice) Madeline Carroll ... Widget / Grace (voice) Victor Bonavida ... Sam (voice) Tony Matthews ... Cora's Dad (voice)
Toni Collette ... Mary Daisy Dinkle (voice) Philip Seymour Hoffman ... Max Jerry Horovitz (voice) Eric Bana ... Damien (voice) Barry Humphries ... Narrator (voice) Bethany Whitmore ... Young Mary (voice) Renée Geyer ... Vera (voice) Ian 'Molly' Meldrum ... Homeless Man (voice) John Flaus ... (voice) Julie Forsyth ... (voice) Michael Ienna ... Lincoln Chris Massey ... Additional Voice Shaun Patten ... Additional Voice Carolyn Shakespeare-Allen ... Additional Voice Leanne Smith ... Additional Voice
Rosario Dawson ... Velvet Von Black (voice) Danny Trejo ... Rico (voice) Paul Giamatti ... Dr. Satan (voice) Sheri Moon Zombie ... Suzi X (voice) Clint Howard ... Joe Cthulu (voice) Bill Moseley ... Otis Driftwood (voice) Sid Haig ... Capt. Spaulding (voice) Geoffrey Lewis ... Lenny (voice) Dee Wallace ... Trixie (voice) Harland Williams ... Gerard the Exterminator (voice) Tom Kenny ... Otto (voice) Cassandra Peterson ... Amber (voice) John Di Maggio ... Burt the Spurt (voice) Brian Posehn ... Murray (voice) Ken Foree ... Luke St. Luke (voice) Daniel Roebuck ... Morris Green (voice) Rob Paulsen ... Commandant Hess / El Gato (voice) Laraine Newman ... Betty Sue Lou (voice) Charles Adler ... Krongarr (voice) Tom Papa ... El Superbeasto (voice) Jess Harnell ... Uncle Carl (voice) Debra Wilson ... The Bride (voice) April Winchell ... Dame Grace Appleton (voice) Tura Satana ... Varla (voice) Joe Alaskey ... Erik the Newscaster (voice)
